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FAR 2024 – Dott. Andrea Ardizzoni – MicroModenaLab

Fondo di Ateneo per la Ricerca (FAR) Dipartimentale

Characterization of probiotic and/or postbiotic activity of Saccharomyces cerevisiae clinical isolates and identification of novel bioactive natural molecules

Saccharomyces cerevisiae is a commensal microorganism that colonizes several sites within the human body. This yeast is widely employed to produce food and fermented
beverages as well as a probiotic in pharmaceutical formulations. Indeed, specific S. cerevisiae strains are being commercialized as probiotics to treat Candida vaginal infections or chronic inflammatory diseases of the gut.

This project aims to expand our preliminary data on the anti-Candida activity of sterile Cell Free Supernatants (CFS) obtained from cultures of S. cerevisiae clinical isolates. Our goal is to increase our knowledge through the evaluation of CFS antimicrobial activity also against bacteria responsible for gastro-intestinal, genital-urinary and cutaneous infections.

Moreover, an untargeted metabolomic approach will be used to detect the presence of bioactive molecules in the CFS. Selected molecules will then be tested in order to evaluate their antioxidant and anti-inflammatory effects on cell lines of gut and vaginal epithelium, as well as on an epidermal cell line.

By analysing the biological activity of different S. cerevisiae strains will improve our understanding of the possible effects stemming from the interaction of this yeast with the gut and vaginal mucosae, as well as with the epidermis.

The results obtained will allow to identify a novel microbial strain with probiotic and/or postbiotic activity; in addition, it will be interesting to establish if such antimicrobial activity is direct or if indirectly impairs the microbes by strengthening the epithelial barrier.